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Possible Mechanism of Tolerance to Narcotic Drugs

 Digital Record
Identifier: 101584577X10


  • Publication: 10 August 1956


2 Pages


While working on the metabolism of narcotic drugs, Axelrod observed that repeated administration of drugs produced tolerance to the drugs, but also reduced the body's ability to demethylate them enzymatically. In this article, he proposed a mechanism for tolerance to narcotic drugs. According to Axelrod, his hypothesis--that the continuous interaction of narcotic drugs with the demethylating enzymes deactivated the enzymes and possibly even the receptors of narcotic drugs, thus decreasing the subject's response to narcotic drugs--stimulated considerable criticism from some of his colleagues.

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Axelrod, Julius. "Possible Mechanism of Tolerance to Narcotic Drugs." Science 124, (10 August 1956): 263-264. Article. 2 Images.


Physical Description

Physical Condition - No Status

Collecting Area Details

Part of the Archives and Modern Manuscripts Collection Collecting Area

8600 Rockville Pike
Bldg 38/1E-21, MSC 3819
Bethesda MD 20894 US
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