Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine

Digital Record

Identifier: 101584577X7

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Dates

Publication: September 1953

Extent

12 pages

Description

This article was the first in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure. Through a variety of tests on several animals, Axelrod found two primary processes, demethylation and hydroxylation, that metabolically transformed ephedrine. He also noted that various animal species showed considerable differences in the relative importance of the two metabolic routes.

Language of Materials

English

Additional Description

Original Profiles System Identifier

HHAAAG

Source Category

Periodical

Axelrod, Julius. "Studies on Sympathomimetic Amines. I. The Biotransformation and Physiological Disposition of l-Ephedrine and l-Norephedrine." Journal of Pharmacology and Experimental Therapeutics 109, 1 (September 1953): 62-73. Article. 12 Images.

Journal of Pharmacology and Experimental Therapeutics