Studies on Sympathomimetic Amines. II. The Biotransformation and Physiological Disposition of D-Amphetamine, D-P-Hydroxyamphetamine and D-Methamphetamine

In this second in a series of papers by Axelrod on the role played in the body by sympathetic amines, a broad class of chemicals that mimic the actions of the sympathetic nervous system and have an amine basic structure, Axelrod found that the fate and physiological disposition of compounds of amphetamine in several species of animals was metabolized by a number of biochemical processes, including hydroxylation, demethylation, deamination, and conjugation. Axelrod again determined that various species showed considerable variations in the ways in which their bodies transformed these drugs.