Oxprenolol vs Propranolol: A Randomized, Double-Blind, Multiclinic Trial in Hypertensive Patients Taking Hydrochlorothiazide

In this article, Freis's team compared oxprenolol and propranolol, both beta-adrenergic blocking agents, in mild and moderate hypertension patients who had not responded well to the diuretic hydrochlorothiazide. They found that after six months a significant reduction in blood pressure occurred in half of the patients that took propranolol along with the diuretic, whereas only twenty-seven percent of the patients that took oxprenolol with a diuretic achieved similar results.