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A Double Blind Control Study of Antihypertensive Agents: I. Comparative Effectiveness of Reserpine, Reserpine and Hydralazine, and Three Ganglionic Blocking Agents, Chlorisondamine, Mecamyamine, and Pentolinium Tartrate

 Digital Record
Identifier: 101584929X61

Dates

  • Publication: July 1960

Extent

16 pages

Description

In 1956, Freis and a group of physicians in several Veterans Administration hospitals organized a cooperative study group to evaluate antihypertensive agents under well-controlled conditions. In this first of three articles, they reported that various therapeutic regimens were compared in a double-blind control study on 326 hypertensive patients, 232 of whom completed a full year of treatment. The group found that a combination of reserpine (a ganglionic-blocking... agent) and hydralazine (a vasodilator) was far more effective than placebos or reserpine alone.

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Language of Materials

English

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