Earl and Thressa Stadtman papers

In 1962 Earl was appointed the chief of the Laboratory of Biochemistry of NHI, and Thressa became a section head in this laboratory twelve years later. Research centered around concept of anaerobic biochemsitry. Thressa Research areas: Vitamin B12: how amino acids are broken down into smaller pieces in the absence of oxygen and how methane gas is produced by some bacteria living in oxygen-free conditions. She showed that vitamin B12 is required for... several enzymes that functioned in these processes. Pioneered the field of selenium biochemistry, by identifying many selenium-containing proteins in cells and explaining the function of selenium in these proteins. Earl research: Fatty Acids Metabolism--showed that "Coenzyme A" (CoA) is involved in the synthesis of fatty acids as a carrier of the small molecular fragment called "acetyl." Cyclic Cascade Systems in Metabolic Regulation--In the 1960s and 70s, discovered some mechanisms of controlling the production of amino acids. Protein Oxidation and Aging--1980s discovered that the accumulation of damaged proteins is closely associated with the aging process and may play a role in age-related diseases such as Parkinson's disease.