An Immunologic Approach to the Conformational Equilibria of Polypeptides

Digital Record

Identifier: 101584571X176

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Digital Object (text)

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Dates

Publication: December 1972

Extent

5 pages

Creator

Anfinsen, Christian B. (Christian Boehmer), 1916-1995 (Creator, Person)

Description

Certain antibodies are particularly well-suited for the study of the conformational equilibria of polypeptide fragments of nuclease in solution. Here, Anfinsen, Schechter, Sachs, and Eastlake hypothesized that such fragments actually existed in solution in conformational equilibrium, components of which were sufficiently similar to the native conformation that antibodies directed to the native molecule could bind. They were able to validate this hypothesis by using synthetic polypeptide fragments, which were already known to induce folding of complimentary fragments.

Language of Materials

English

Additional Description

Original Profiles System Identifier

KKBBLL

Source Category

Periodical

Sachs, David H., Alan N. Schechter, Ann Eastlake, and Christian B. Anfinsen. "An Immunologic Approach to the Conformational Equilibria of Polypeptides." Proceedings of the National Academy of Sciences of the United States of America 69, 12 (December 1972): 3790-3794. Article. 5 Images.

Proceedings of the National Academy of Sciences of the United States of America