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A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase

 Digital Record
Identifier: 101584571X143

Dates

  • Publication: 1962

Extent

9 Pages

Description

In this article, Anfinsen, Epstein, Goldberger, and Young reported their findings of the rate and extent of return of enzymatic activity during oxidation of the sulfhydryl groups of reduced ribonuclease that they studied under a variety of conditions. They found that the rate of reactivation was inversely proportional to the concentration of the reduced portion of ribonuclease. Because of this, these results were inconsistent with the then-prevailing hypothesis that information necessary for the conversion of a newly synthesized polypeptide chain to the native form of the protein resided in the amino acid sequence and did not involve a genetically determined template.

Language of Materials

English

Original Profiles System Identifier

KKBBJW

Source Category

Periodical

Epstein, Charles, Robert Goldberger, D. Michael Young, and Christian B. Anfinsen. "A Study of the Factors Influencing the Rate and Extent of Enzymic Reactivation during Reoxidation of Reduced Ribonucelase." Archives of Biochemistry and Biophysics Supplement, (1962): 223-231. Article. 9 Images.

Archives of Biochemistry and Biophysics

Physical Description

Physical Condition - Good

Collecting Area Details

Part of the Archives and Modern Manuscripts Collection Collecting Area

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