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Fluorescence Studies of the Interaction of Nucleotides with the Active Site of the Nuclease of Staphylococcus aureus

 Digital Record
Identifier: 101584571X150
Digital Object (text)

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Dates

  • Publication: November 1967

Extent

8 pages

Creator

Description

In the late 1960s, Anfinsen's lab sought to understand the complicated details of the physicochemical properties of Staphylococcus aureus in solution, ultimately to better understand the relationship of its structure to its function. In this article, Anfinsen, Cuatrecasas, and Edelhoch reported that the specific binding of a competitive inhibitor resulted in a marked decrease in tyrosyl fluorescence, which they interpreted as indicative of a specific... interaction of the nucleotide with several tyrosyl groups in the active site of the enzyme.

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Language of Materials

English

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