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Some Relationships of Structure to Function in Ribonuclease

 Digital Record
Identifier: 101584571X166


  • Publication: 4 September 1959


9 Pages



This study by White and Anfinsen on the renaturation of fully denatured ribonuclease, or RNase, required subsequent supporting investigations to establish what came to be called the "thermodynamic hypothesis." Here they reported that RNase activity depended upon a variety of structural features, but noted that it could be inferred from the results of their experimentation that only a small part of the enzyme molecule, what they termed the "active center," was necessary for catalyst.

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White, F. H. Jr, and Christian B. Anfinsen. "Some Relationships of Structure to Function in Ribonuclease." Annals of the New York Academy of Sciences 81, 3 (4 September 1959): 515-523. Article. 9 Images.

Annals of the New York Academy of Sciences

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Physical Condition - Good

Collecting Area Details

Part of the Archives and Modern Manuscripts Collection Collecting Area

8600 Rockville Pike
Bldg 38/1E-21, MSC 3819
Bethesda MD 20894 US
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