Nuclease-T: An Active Derivative of Staphylococcal Nuclease Composed of Two Noncovalently Bonded Peptide Fragments

This is one of many articles produced by Anfinsen's research team and others on the factors contributing to the translation of the genetic message for a particular protein backbone. Taniuchi, Sodja, and Anfinsen determined that such a translation was no longer possible if the linear information had been manipulated through the deletion of amino acid residues. However, they did find that some proteins that they termed "recombining systems" could be cleaved into two, or even three, fragments that recombined through non-covalent forces to yield biologically active structures with physical properties very similar to those of the parent protein molecules.