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Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme

 Digital Record
Identifier: 101584571X173

Dates

  • Publication: October 1969

Extent

8 Pages

Description

After discovering an error in their original primary sequence analysis of staphylococcal nuclease, in which residue 43 was misidentified as glutamine instead of glutamic acid, Ontjes and Anfinsen published this paper. They reported that a resynthesis of the correct sequence in turn yielded a product with high biological activity. Therefore, they concluded that residue 43, although not essential for folding, was very important for catalytic activity once folding had occurred.

Language of Materials

English

Original Profiles System Identifier

KKBBLH

Source Category

Periodical

Ontjes, David, and Christian B. Anfinsen. "Solid Phase Synthesis of a 42-Residue Fragment of Staphylococcal Nuclease: Properties of a Semisynthetic Enzyme." Proceedings of the National Academy of Sciences of the United States of America 64, 2 (October 1969): 428-435. Article. 8 Images.

Proceedings of the National Academy of Sciences of the United States of America

Relation Category

UI (NLM)

KKBBKD

Physical Description

Physical Condition - Good

Collecting Area Details

Part of the Archives and Modern Manuscripts Collection Collecting Area

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